Kill Satan with Samson.
Kill Satan with Cain.
Kill Isaac with Cain.
Beat Sheol 5 times.
Kill Mom's Heart 11 times.
You are the best!
Beat the Chest.
Kill Satan with Maggy.
Kill Isaac with Samson.
Beat Cathedral 5 times.
Beat the Caves 30 times.
Kill Isaac with Isaac.
Beat the Depths 20 times.
Beat the Chest or Dark Room without taking damage.
Beat the Basement 40 times.
Beat the Dark Room with Isaac.
Kill Isaac with Lazarus.
Kill Isaac with Maggy.
Beat the Dark Room.
Kill Mom's Heart 10 times.
Beat the Boss Rush.
Kill Mom's Heart 9 times.
Kill Mom's Heart 8 times.
Kill Satan with Isaac.
Beat the Depths/Necropolis without taking damage.
Beat the Womb/Utero without taking damage.
Kill Isaac with Azazel.
Kill Mom's Heart 5 times.
Kill Satan with Lazarus.
Kill Satan with Azazel.
Kill Satan
Beat 2 levels in a row without picking up any hearts.
Beat the Caves/Catacombs without taking damage.
Kill all 7 sins.
Kill Mom's Heart 3 times.
Have 7 or more max red hearts at one time.
Beat 2 levels in a row without taking damage.
Beat the Basement/Cellar without taking damage.
Beat the Womb for the first time,
Make 3 deals with the devil in one run.
Hold 55 or more pennies at one time.
Kill Mom using the Bible.
Kill Mom.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Have 4 or more soul hearts at one time
Kill Isaac with Eden.
Kill Satan with Eden.
Kill Isaac with Eve.
Kill Satan with Eve.
Kill Satan with ???.
Kill Isaac with Judas.
Kill Satan with Judas.
Finish the game's final secret.
Kill Isaac with The Lost.
Kill Satan with The Lost.
Beat all 20 Challenges.
Collect all items and unlock all secrets and endings.
100% the game!
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Unlocked a new area
Beat Delirium
Just Stop!
Kill Mega Satan
Donate 500 coins to the Greed Machine
Kill The Lamb
Uncover some lost remains..